How to programmatically break prefab instance upon pressing Play

Is there a way to break a prefab connection in script when I hit the Play button (or when the game starts)? I'm using an asset from the asset store that does not work in play mode unless the connection on it is broken. I know of PrefabUtility.DisconnectPrefabInstance, but it appears like it can only be executed in Edit mode? Is this true? Thanks!